Celleavbildning og fortolkning

Modern biological medicine is largely based on the understanding of the cell as basic unit in all living organisms. Knowledge about the normal microscopic appearance of cells and tissues is at the core of morphology. The course provides an overview of different methods for the study of tissue and cell structure, emphasising the respective advantages and limitations of different preparative procedures for light and electron microscopic visualisation. The course will give the students practical skills in preparation and microscopy of biological specimens. A main focus will be on interpretation of tissue and cell morphology.

After completing the course MOL3017, the student should be able to:
- describe the construction of an ordinary, compound microscope, and name the constituting parts
- describe the path of the light through the microscope and explain in detail the overall function of the microscope and that of its parts
- make efficient use of an ordinary light microscope, including necessary adjustments
- explain the main principles of fluorescence, phase contrast, differential intereference contrast and dark field microscopy
- describe the main principles of preparation of cells and tissues for light and electron microscopy
- describe the most important artefacts which may occur when applying various preparatory methods for light and electron microscopy, and explain the underlying mechanisms
- describe the different tissues of a mammalian organism, indicate their main functions, and describe how the structure is adapted to the functional tasks
- identify and characterize different cell and tissue types in microscopic preparations, and recognize the organ of origin
- recognize large deviations from normal light microscopic appearance of cells and tissues, and suggest underlying mechanisms and possible causes
- define the term morphometry and explain the main principles of stereological morphometry
- discuss advantages and limitations of various quantitative methods in morphology
- preparing, sectioning and documenting biological specimens.

Lectures, practical training sessions, and demonstrations. If many candidates, alternative examination arrangements may be used.

Restricted admission. Students admitted to the Master's Programme in Molecular Medicine will have priority.

Timetables at the Faculty of Medicine will be available here:
https://timeplan.medisin.ntnu.no/timetable_show.php?page=search